Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages.

Details

Serval ID
serval:BIB_1302D7181516
Type
Article: article from journal or magazin.
Collection
Publications
Title
Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages.
Journal
European Journal of Immunology
Author(s)
Marsland B.J., Kurrer M., Reissmann R., Harris N.L., Kopf M.
ISSN
0014-2980
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
38
Number
2
Pages
479-488
Language
english
Abstract
Chronic obstructive pulmonary disease (COPD) is the 5(th) most prevalent disease worldwide leading to severe morbidity and mortality in developed countries. The disease is strongly associated with smoking, and can be characterized by progressive and irreversible deterioration in lung function and destruction of the lung parenchyma. We show here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long-term airways hyperresponsiveness, consistent with COPD and emphysema. N. brasiliensis infection leads to chronic low level hemorrhaging in the lung and the presence of hemosiderin-laden macrophages in the absence of an overt inflammatory infiltrate. Microarray analysis of gene expression in diseased lungs and quantitative RT-PCR analysis of purified macrophages revealed a state of prolonged tissue injury and the presence of alternatively activated macrophages producing MMP-12. Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema.
Keywords
Animals, Antigens, Helminth/immunology, Bronchial Hyperreactivity/enzymology, Bronchial Hyperreactivity/immunology, Chronic Disease, Lung/enzymology, Lung/immunology, Macrophage Activation/immunology, Macrophages/enzymology, Macrophages/immunology, Matrix Metalloproteinase 12/biosynthesis, Matrix Metalloproteinase 12/physiology, Mice, Mice, Inbred BALB C, Mice, Knockout, Nippostrongylus/immunology, Pulmonary Emphysema/immunology, Pulmonary Emphysema/parasitology, Rats, Rats, Inbred Lew, Strongylida Infections/enzymology, Strongylida Infections/immunology
Pubmed
Web of science
Open Access
Yes
Create date
18/01/2010 13:05
Last modification date
20/08/2019 12:41
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