Morphogenesis and renewal of hair follicles from adult multipotent stem cells
Details
Serval ID
serval:BIB_12F37C82192C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Morphogenesis and renewal of hair follicles from adult multipotent stem cells
Journal
Cell
ISSN
0092-8674 (Print)
Publication state
Published
Issued date
01/2001
Volume
104
Number
2
Pages
233-45
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan 26
Research Support, Non-U.S. Gov't --- Old month value: Jan 26
Abstract
The upper region of the outer root sheath of vibrissal follicles of adult mice contains multipotent stem cells that respond to morphogenetic signals to generate multiple hair follicles, sebaceous glands, and epidermis, i.e., all the lineages of the hairy skin. At the time when hair production ceases and when the lower region of the follicle undergoes major structural changes, the lower region contains a significant number of clonogenic keratinocytes, and can then respond to morphogenetic signals. This demonstrates that multipotent stem cells migrate to the root of the follicle to produce whisker growth. Moreover, our results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.
Keywords
Animals
Cell Lineage
Cell Movement
Cells, Cultured
Chimera
Colony-Forming Units Assay
Embryo/physiology
Epidermis/cytology/growth & development
Female
Genes, Reporter
Hair Follicle/cytology/*growth & development/transplantation
Immunohistochemistry
Keratinocytes/cytology/metabolism
Male
Mice
Mice, Inbred Strains
Morphogenesis
Rats
Rats, Inbred F344
Stem Cells/*physiology
Vibrissae/anatomy & histology/*growth & development/physiology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 9:41
Last modification date
20/08/2019 13:41