The HIV-1 long terminal repeat contains an unusual element that induces the synthesis of short RNAs from various mRNA and snRNA promoters.

Détails

ID Serval
serval:BIB_12BEFCA45A3A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The HIV-1 long terminal repeat contains an unusual element that induces the synthesis of short RNAs from various mRNA and snRNA promoters.
Périodique
Genes and Development
Auteur(s)
Ratnasabapathy R., Sheldon M., Johal L., Hernandez N.
ISSN
0890-9369[print], 0890-9369[linking]
Statut éditorial
Publié
Date de publication
12/1990
Volume
4
Numéro
12A
Pages
2061-2074
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
We describe an unusual element that activates the synthesis of short transcripts from a wide variety of mRNA and small nuclear RNA (snRNA) promoters, including the U6 RNA polymerase III promoter. This inducer of short transcripts (IST) is located between positions -5 and +82 relative to the cap site in the HIV-1 LTR. In the presence of IST, the total transcriptional activity of the different promoters is greatly increased, but the resulting additional RNA molecules are short, ending around position +60. IST is not the RNA target (TAR) for Tat trans-activation; however, because it relies entirely on cellular factors for activity, IST may serve to provide abundant RNA targets for Tat trans-activation without a requirement for full-length viral mRNA expression.
Mots-clé
Base Sequence, Genes, tat, HIV Long Terminal Repeat, HIV-1/genetics, Molecular Sequence Data, Nucleic Acid Conformation, Promoter Regions, Genetic, RNA Polymerase II/genetics, RNA Polymerase II/metabolism, RNA Polymerase III/genetics, RNA Polymerase III/metabolism, RNA, Messenger/metabolism, RNA, Small Nuclear/genetics, RNA, Viral/biosynthesis, Restriction Mapping, Transcription, Genetic, Transcriptional Activation
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 17:34
Dernière modification de la notice
20/08/2019 13:41
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