Article: article from journal or magazin.
Levocetirizine better protects than desloratadine in a nasal provocation with allergen
Journal of Allergy and Clinical Immunology
Clinical Trial Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't
BACKGROUND: Direct comparisons of antihistamines are rare but very much needed. Newly available antihistamine preparations, levocetirizine, the R-enantiomer of racemate cetirizine, and desloratadine, an active metabolite of loratadine, have been recently released for allergic rhinitis. OBJECTIVE: We sought to compare levocetirizine and desloratadine in a nasal provocation test (NPT) with grass pollen. METHODS: Twenty-four volunteers with grass pollen allergy and a history of rhinitis were enrolled in a double-blind, placebo-controlled, crossover study. Three NPTs were performed in a dose-escalating manner during the out-of-season period 4 hours after a single dose of levocetirizine (5 mg), desloratadine (5 mg), or placebo. RESULTS: CONCLUSIONS: This study demonstrates a better overall protection of a single dose of levocetirizine compared with desloratadine in an NPT with grass pollen allergen. In contrast to late-phase inflammatory markers, which were unaffected, extravascular leakage of the early-phase marker albumin was significantly limited by levocetirizine.
Adult Albumins/metabolism Allergens/*immunology Biological Markers/analysis Cetirizine/*therapeutic use Cross-Over Studies Differential Threshold Double-Blind Method Female Histamine H1 Antagonists, Non-Sedating/*therapeutic use Humans Hypersensitivity/*drug therapy/physiopathology Loratadine/*analogs & derivatives/*therapeutic use Male Nasal Lavage Fluid/chemistry Nasal Provocation Tests Piperazines/*therapeutic use Poaceae/*immunology Pollen/*immunology Treatment Outcome
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