Are TADs supercoiled?

Détails

Ressource 1Télécharger: 30395328_BIB_12BCCBEC8B1A.pdf (1993.87 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_12BCCBEC8B1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Are TADs supercoiled?
Périodique
Nucleic acids research
Auteur(s)
Racko D., Benedetti F., Dorier J., Stasiak A.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
25/01/2019
Peer-reviewed
Oui
Volume
47
Numéro
2
Pages
521-532
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Topologically associating domains (TADs) are megabase-sized building blocks of interphase chromosomes in higher eukaryotes. TADs are chromosomal regions with increased frequency of internal interactions. On average a pair of loci separated by a given genomic distance contact each other 2-3 times more frequently when they are in the same TAD as compared to a pair of loci located in two neighbouring TADs. TADs are also functional blocks of chromosomes as enhancers and their cognate promoters are normally located in the same TAD, even if their genomic distance from each other can be as large as a megabase. The internal structure of TADs, causing their increased frequency of internal interactions, is not established yet. We survey here experimental studies investigating presence of supercoiling in interphase chromosomes. We also review numerical simulation studies testing whether transcription-induced supercoiling of chromatin fibres can explain how TADs are formed and how they can assure very efficient interactions between enhancers and their cognate promoters located in the same TAD.
Mots-clé
Chromatin, Chromosomes/chemistry, DNA, Superhelical, Enhancer Elements, Genetic, Models, Genetic, Promoter Regions, Genetic, Transcription, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/11/2018 12:39
Dernière modification de la notice
12/09/2019 5:10
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