Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_12AA1B08BAC1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Review on Antifungal Resistance Mechanisms in the Emerging Pathogen Candida auris.
Journal
Frontiers in microbiology
Author(s)
Chaabane F., Graf A., Jequier L., Coste A.T.
ISSN
1664-302X (Print)
ISSN-L
1664-302X
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
10
Pages
2788
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Candida auris is an emerging multi-drug resistant yeast, that causes major issues regarding patient treatment and surface disinfection in hospitals. Indeed, an important proportion of C. auris strains isolated worldwide present a decreased sensitivity to multiple and sometimes even all available antifungals. Based on recent tentative breakpoints by the CDC, it appears that in the USA about 90, 30, and < 5% of isolates have been resistant to fluconazole, amphotericin B, and echinocandins, respectively. To date, this has lead to a low therapeutic success. Furthermore, C. auris is prone to cause outbreaks, especially since it can persist for weeks in a nosocomial environment and survive high-end disinfection procedures. In this review, we describe the molecular resistance mechanisms to antifungal drugs identified so far in C. auris and compare them to those previously discovered in other Candida species. Additionally, we examine the role that biofilm formation plays in the reduced antifungal sensitivity of this organism. Finally, we summarize the few insights on how this yeast survives on hospital surfaces and discuss the challenge it presents regarding nosocomial environment disinfection.
Keywords
Candida auris, MIC, antifungal resistance, biofilm, emerging pathogen, outbreaks
Pubmed
Web of science
Open Access
Yes
Create date
19/12/2019 11:20
Last modification date
28/01/2021 7:08
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