Diffuse jejuno-ileitis of Crohn’s disease: a separate form of the disease?

Details

Serval ID
serval:BIB_11CDC5440A89
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diffuse jejuno-ileitis of Crohn’s disease: a separate form of the disease?
Journal
Gastroenterol Clin Biol
Author(s)
Touze I., Gower-Rousseau C., Grandbastien B., Paris J. C., Quandalle P., Cortot A., Colombel J. F.
Publication state
Published
Issued date
03/1999
Volume
23
Number
3
Pages
307-11
Language
french
Abstract
BACKGROUND AND AIMS: Diffuse jejuno-ileitis of Crohn’s disease may be a homogeneous clinical subgroup. The aim of this work was to compare the demographic and clinical data at diagnosis and the initial treatments of patients with diffuse jejuno-ileitis of Crohn’s disease and to the ones without this localization. PATIENTS AND METHODS: For demographic and clinical studies, 48 (32M/16F) incident cases of diffuse jejuno-ileitis of Crohn’s disease diagnosed between 1988 and 1994 in the EPIMAD register were compared with 96 (48M/48F) controls diagnosed the same year. As far as for the therapeutic management, the 48 incident cases were compared with 48 controls. RESULTS: Diffuse jejuno-ileitis constituted 3.3% of the total incident cases. Median age at diagnosis was significantly lower (20 vs 23 years, P = 0.01) and an upper digestive involvement was more frequent (56% vs 34%, P = 0.03) in patients with diffuse jejuno-ileitis. These patients were more often treated by total parenteral nutrition (43.8% vs 19.6%, P = 0.01) or azathioprine (50% vs 20.8%, P = 0.005). Azathioprine was also introduced earlier (20.7 vs 40.3 months, P = 0.009). Surgery for resection was less often required in diffuse jejuno-ileitis than in controls (65.2% vs 99.8%, P = 0.02) while more stricturoplasties were performed (52.9% vs 10%, P = 0.003); overall surgical rates did not significantly differ in the 2 groups. CONCLUSION: Our series suggest that diffuse jejuno-ileitis of Crohn’s disease is a subgroup of patients characterized by a young age at diagnosis, with more frequent and earlier requirement for azathioprine.
Keywords
Adolescent, Adult, Aging, Azathioprine/therapeutic use, Crohn Disease/pathology/*therapy, Enteritis/pathology/*therapy, Female, Humans, Ileal Diseases/pathology/*therapy, Jejunal Diseases/pathology/*therapy, Male, Middle Aged, Parenteral Nutrition, Total
Create date
18/07/2019 12:48
Last modification date
21/08/2019 5:33
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