Article: article from journal or magazin.
PAC1 null females display decreased fertility
Annals of the New York Academy of Sciences
We report here that PAC1 KO females display decreased fertility, whereas male fertility was normal. ICC on pituitary section showed that FSH, LH, and prolactin synthesis were not affected in KO mice. Moreover, the pituitary-gonadal axis responded properly to an acute fasting test in KO mice. Hence, the phenotype of PAC1 null mice provides clear evidence for the role of PAC1 receptor in reproduction process.
Animals Female Fertility/*genetics/*physiology Follicle Stimulating Hormone/metabolism Immunohistochemistry Luteinizing Hormone/metabolism Male Mice Mice, Knockout Phenotype Pituitary Gland, Anterior/physiology Pregnancy Prolactin/metabolism Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I Receptors, Pituitary Hormone/*genetics/*physiology Seminal Vesicles/physiology Sex Characteristics Uterus/physiology
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