PAC1 null females display decreased fertility

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Serval ID
serval:BIB_11C3587D9078
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
PAC1 null females display decreased fertility
Journal
Annals of the New York Academy of Sciences
Author(s)
Jamen  F., Rodriguez-Henche  N., Pralong  F., Jegou  B., Gaillard  R., Bockaert  J., Brabet  P.
ISSN
0077-8923 (Print)
Publication state
Published
Issued date
2000
Volume
921
Pages
400-4
Notes
Journal Article
Abstract
We report here that PAC1 KO females display decreased fertility, whereas male fertility was normal. ICC on pituitary section showed that FSH, LH, and prolactin synthesis were not affected in KO mice. Moreover, the pituitary-gonadal axis responded properly to an acute fasting test in KO mice. Hence, the phenotype of PAC1 null mice provides clear evidence for the role of PAC1 receptor in reproduction process.
Keywords
Animals Female Fertility/*genetics/*physiology Follicle Stimulating Hormone/metabolism Immunohistochemistry Luteinizing Hormone/metabolism Male Mice Mice, Knockout Phenotype Pituitary Gland, Anterior/physiology Pregnancy Prolactin/metabolism Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I Receptors, Pituitary Hormone/*genetics/*physiology Seminal Vesicles/physiology Sex Characteristics Uterus/physiology
OAI-PMH
oai:serval.unil.ch:BIB_11C3587D9078
Pubmed
11193864
Web of science
000171939800059
Create date
25/01/2008 17:26
Last modification date
20/08/2019 13:39
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