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Can MMTV exploit TLR4?
Trends in Microbiology
The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response. A recent publication proposed that the retrovirus mouse mammary tumor virus exploits the pattern-recognition receptor Toll-like receptor 4 to achieve more efficient infection.
Animals, B-Lymphocytes/immunology, B-Lymphocytes/virology, Drosophila Proteins, Mammary Tumor Virus, Mouse/immunology, Membrane Glycoproteins/genetics, Membrane Glycoproteins/immunology, Mice, Receptors, Cell Surface/genetics, Receptors, Cell Surface/immunology, Toll-Like Receptor 4, Toll-Like Receptors, Viral Envelope Proteins/immunology
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