Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals.
Details
Serval ID
serval:BIB_115F50FB318B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Life-course socioeconomic disadvantage and lung function: a multicohort study of 70 496 individuals.
Journal
The European respiratory journal
Working group(s)
LIFEPATH Consortium, members of the LIFEPATH Consortium (in alphabetical order):
Contributor(s)
Alberts J., Alenius H., Avendano M., Baglietto L., Baltar V., Barros H., Bartley M., Bellone M., Berger E., Blane D., Bochud M., Candiani G., Carmeli C., Carra L., Castagne R., Chadeau-Hyam M., Cima S., Costa G., Courtin E., Delpierre C., D'Errico A., Donkin A., Dugue P.A., Elliott P., Fagherazzi G., Fiorito G., Fraga S., Gandini M., Gares V., Gerbouin-Rerolle P., Giles G., Goldberg M., Greco D., Hodge A., Karimi M., Karisola P., Kelly-Irving M., Kivimaki M., Laine J., Lang T., Laurent A., Layte R., Lepage B., Lorsch D., Machell G., Mackenbach J., Marmot M., McCrory C., de Mestral C., Miller C., Milne R., Muennig P., Nusselder W., Petrovic D., Pilapil L., Polidoro S., Preisig M., Ribeiro A.I., Ricceri F., Recalcati P., Reinhard E., Robinson O., Valverde J.R., Saba S., Santegoets F., Severi G., Simmons T., Stringhini S., Tabak A., Terhi V., Tieulent J., Vaccarella S., Vigna-Taglianti F., Vineis P., Vollenweider P., Zins M.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
03/2021
Peer-reviewed
Oui
Volume
57
Number
3
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Lung function is an important predictor of health and a marker of physical functioning at older ages. This study aimed to quantify the years of lung function lost according to disadvantaged socioeconomic conditions across the life-course.
This multicohort study used harmonised individual-level data from six European cohorts with information on life-course socioeconomic disadvantage and lung function assessed by forced expiratory volume in 1 s (FEV <sub>1</sub> ) and forced vital capacity (FVC). 70 496 participants (51% female) aged 18-93 years were included. Socioeconomic disadvantage was measured in early life (low paternal occupational position), early adulthood (low educational level) and adulthood (low occupational position). Risk factors for poor lung function (e.g. smoking, obesity, sedentary behaviour, cardiovascular and respiratory diseases) were included as potential mediators. The years of lung function lost due to socioeconomic disadvantage were computed at each life stage.
Socioeconomic disadvantage during the life-course was associated with a lower FEV <sub>1</sub> . By the age of 45 years, individuals experiencing disadvantaged socioeconomic conditions had lost 4-5 years of healthy lung function versus their more advantaged counterparts (low educational level -4.36 (95% CI -7.33--2.37) for males and -5.14 (-10.32--2.71) for females; low occupational position -5.62 (-7.98--4.90) for males and -4.32 (-13.31--2.27) for females), after accounting for the risk factors for lung function. By the ages of 65 years and 85 years, the years of lung function lost due to socioeconomic disadvantage decreased by 2-4 years, depending on the socioeconomic indicator. Sensitivity analysis using FVC yielded similar results to those using FEV <sub>1</sub> .
Life-course socioeconomic disadvantage is associated with lower lung function and predicts a significant number of years of lung function loss in adulthood and at older ages.
This multicohort study used harmonised individual-level data from six European cohorts with information on life-course socioeconomic disadvantage and lung function assessed by forced expiratory volume in 1 s (FEV <sub>1</sub> ) and forced vital capacity (FVC). 70 496 participants (51% female) aged 18-93 years were included. Socioeconomic disadvantage was measured in early life (low paternal occupational position), early adulthood (low educational level) and adulthood (low occupational position). Risk factors for poor lung function (e.g. smoking, obesity, sedentary behaviour, cardiovascular and respiratory diseases) were included as potential mediators. The years of lung function lost due to socioeconomic disadvantage were computed at each life stage.
Socioeconomic disadvantage during the life-course was associated with a lower FEV <sub>1</sub> . By the age of 45 years, individuals experiencing disadvantaged socioeconomic conditions had lost 4-5 years of healthy lung function versus their more advantaged counterparts (low educational level -4.36 (95% CI -7.33--2.37) for males and -5.14 (-10.32--2.71) for females; low occupational position -5.62 (-7.98--4.90) for males and -4.32 (-13.31--2.27) for females), after accounting for the risk factors for lung function. By the ages of 65 years and 85 years, the years of lung function lost due to socioeconomic disadvantage decreased by 2-4 years, depending on the socioeconomic indicator. Sensitivity analysis using FVC yielded similar results to those using FEV <sub>1</sub> .
Life-course socioeconomic disadvantage is associated with lower lung function and predicts a significant number of years of lung function loss in adulthood and at older ages.
Pubmed
Web of science
Create date
28/11/2020 10:53
Last modification date
27/06/2021 6:37
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