Non-compliance with recommendations for the practice of antibiotic prophylaxis and risk of surgical site infection: results of a multilevel analysis from the INCISO Surveillance Network

Details

Serval ID
serval:BIB_1153313BF087
Type
Article: article from journal or magazin.
Collection
Publications
Title
Non-compliance with recommendations for the practice of antibiotic prophylaxis and risk of surgical site infection: results of a multilevel analysis from the INCISO Surveillance Network
Journal
Journal of Antimicrobial Chemotherapy
Author(s)
Miliani Katiuska, L'Hériteau François, Astagneau Pascal
Working group(s)
INCISO Network Study Group
Contributor(s)
Grandbastien Bruno, et al.
ISSN
1460-2091
0305-7453
Publication state
Published
Issued date
12/2009
Volume
64
Number
6
Pages
1307-1315
Language
english
Abstract
Objectives
The aim of this study was to determine which surgical antibiotic prophylaxis (SAP) practices alter surgical site infection (SSI) risk.
Methods
Data were collected during a 7 year surveillance period (2001–07) from volunteer surgery wards participating in the INCISO Surveillance Network in Northern France. Main SAP practices, i.e. antibiotic choice, timing of first dose and total SAP duration, were evaluated and compliance checked based on French recommendations. The study focused on selected procedures in digestive, orthopaedic, gynaecological and cardiovascular surgery, for which standard SAP is recommended. Multilevel logistic regression analysis (a two-level random effect model) was carried out to identify SAP-, patient- and procedure-specific factors associated with SSI.
Results
Of 8029 patients who underwent the selected surgeries, 91.3% received SAP and 2.5% developed SSI. Among those receiving SAP, 83.3% received appropriate antibiotic agents and 76.6% had an optimal timing of administration. SAP duration was considered to be appropriate in 35.0%, too long (SAP unnecessarily prolonged) in 45.2% and too short (lack of intra-operative redosing when recommended) in 19.8%. In the multivariate analysis, a too-short SAP duration remained the only inappropriate practice associated with higher SSI risk (odds ratio = 1.8, 95% confidence interval: 1.14–2.81), after adjustment for surgery procedure group, the National Nosocomial Infections Surveillance System risk index, age and infection risk variability among hospitals. No significant relationships were observed between SSI and the other SAP parameters.
Conclusions
A too-short SAP duration was the most important SAP malpractice associated with an increased risk of SSI. Information directed at practitioners should be reinforced based on standard recommendations.
Keywords
Pharmacology (medical), Pharmacology, Infectious Diseases, surgical antibiotic prophylaxis, practice assessment, multilevel logistic regression analysis,
Pubmed
Web of science
Open Access
Yes
Create date
19/07/2019 11:03
Last modification date
21/08/2019 5:33
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