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Mutations in the cdc10 start gene of Schizosaccharomyces pombe implicate the region of homology between cdc10 and SWI6 as important for p85cdc10 function.
Molecular and General Genetics
The cdc10 gene of the fission yeast Schizosaccharomyces pombe is required for traverse of start and commitment to the mitotic cell division cycle rather than other fates. The product of the gene, p85cdc10, is a component of a factor that is thought to be involved in regulating the transcription of genes that are required for DNA synthesis. In order to define regions of the p85cdc10 protein that are important for its function a fine structure genetic map of the cdc10 gene was derived and the sequences of 13 cdc10ts mutants determined. The 13 mutants tested define eight alleles. Eleven of the mutants are located in the region that contains the two copies of the cdc10/SWI6 repeat motif, implicating it as important for p85cdc10 function.
Amino Acid Sequence, Base Sequence, Cell Cycle, Cell Cycle Proteins, Chromosome Mapping, DNA Mutational Analysis, Fungal Proteins/genetics, GTP Phosphohydrolases, Genes, Fungal, Membrane Proteins, Molecular Sequence Data, Oligodeoxyribonucleotides/chemistry, Polymerase Chain Reaction, Saccharomyces cerevisiae Proteins, Schizosaccharomyces/genetics, Schizosaccharomyces pombe Proteins, Sequence Alignment, Structure-Activity Relationship, Transcription Factors/genetics
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