Colloidal systems for the delivery of cyclosporin A to the anterior segment of the eye.

Details

Serval ID
serval:BIB_111BFA57E4DA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Colloidal systems for the delivery of cyclosporin A to the anterior segment of the eye.
Journal
Annales Pharmaceutiques Françaises
Author(s)
Di Tommaso C., Behar-Cohen F., Gurny R., Möller M.
ISSN
0003-4509 (Print)
ISSN-L
0003-4509
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
69
Number
2
Pages
116-123
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Due to the eye's specific anatomical and physiological conformation, the treatment of eye diseases is a real challenge for pharmaceutical therapy. The presence of efficient protective barriers (i.e., the conjunctival and corneal membranes) and protective mechanisms (i.e., blinking and nasolachrymal drainage) makes this organ particularly impervious to local drug therapy. To overcome these issues, numerous strategies have been envisioned using pharmaceutical technology. Many formulations currently on the market or still under development are emulsions or colloidal systems intended to enhance precorneal residence time and corneal penetration, causing a consequent increase in drug bioavailability after instillation. After a review of some recent developments in the field of cyclosporin A formulations for the eye, a novel micellar formulation of cyclosporine A based on a diblock methoxy-poly(ethylene glycol)-hexysubstituted poly(lactides) (MPEG-hexPLA) is described.
Keywords
Animals, Anterior Eye Segment, Chemistry, Pharmaceutical, Colloids, Cyclosporine/administration & dosage, Cyclosporine/therapeutic use, Drug Delivery Systems, Emulsions, Humans, Micelles, Nanoparticles, Ophthalmic Solutions, Polyesters, Polyethylene Glycols
Pubmed
Create date
22/08/2013 14:20
Last modification date
20/08/2019 12:38
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