A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells.

Détails

ID Serval
serval:BIB_110080D02FA8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells.
Périodique
Cell
Auteur(s)
Hemmi S., Böhni R., Stark G., Di Marco F., Aguet M.
ISSN
0092-8674 (Print)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
1994
Volume
76
Numéro
5
Pages
803-810
Langue
anglais
Résumé
Expression of the human interferon gamma receptor (IFN-gamma R) in mouse cells is not sufficient to confer biological responsiveness to human IFN-gamma and vice versa. An additional species-specific component is required for signal transduction. We identified this cofactor by expression cloning in simian COS cells stably transfected with the nonfunctional murine IFN-gamma R and a IFN-gamma-inducible reporter construct encoding the human Tac antigen (interleukin-2 receptor alpha chain, CD25). A cDNA clone was obtained that, upon stable transfection, rendered human HEp-2 cells expressing the murine IFN-gamma R fully responsive to murine IFN-gamma. This cDNA encodes a novel 332 amino acid type I transmembrane protein that belongs to the IFN receptor family and that we designate IFN-gamma R beta chain.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, Chromosomes, Human, Pair 21, Cloning, Molecular, DNA, Complementary/genetics, Genes, Genetic Complementation Test, Humans, Mice, Molecular Sequence Data, Receptors, Interferon/chemistry, Receptors, Interferon/genetics, Sequence Alignment, Sequence Homology, Amino Acid
Pubmed
Web of science
Création de la notice
28/01/2008 12:36
Dernière modification de la notice
03/03/2018 13:50
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