Sofosbuvir add-on to ribavirin for chronic hepatitis E in a cirrhotic liver transplant recipient: a case report.

Détails

ID Serval
serval:BIB_10FD0B1931C2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Sofosbuvir add-on to ribavirin for chronic hepatitis E in a cirrhotic liver transplant recipient: a case report.
Périodique
BMC gastroenterology
Auteur(s)
Fraga M., Gouttenoire J., Sahli R., Chtioui H., Marcu C., Pascual M., Moradpour D., Vionnet J.
ISSN
1471-230X (Electronic)
ISSN-L
1471-230X
Statut éditorial
Publié
Date de publication
24/05/2019
Peer-reviewed
Oui
Volume
19
Numéro
1
Pages
76
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Chronic hepatitis E represents an emerging challenge in organ transplantation, as there are currently no established treatment options for patients who fail to clear hepatitis E virus (HEV) following reduction of immunosuppressive therapy and/or treatment with ribavirin. Sofosbuvir has shown antiviral activity against HEV in vitro but clinical utility in vivo is unknown.
We describe a 57-year-old liver transplant recipient with decompensated graft cirrhosis due to chronic hepatitis E. Reduction of immunosuppressive treatment as well ribavirin alone for 4 months did not result in viral clearance. Add-on of sofosbuvir for 6 months was associated with HEV RNA becoming undetectable in plasma. However, sustained viral clearance could not be achieved.
Sofosbuvir may have some antiviral activity against HEV when added to ribavirin. However, this did not suffice to yield sustained viral clearance. Our well-characterized observation emphasizes the need for new treatment options to cure chronic hepatitis E in the setting of organ transplantation.
Mots-clé
Chronic hepatitis, Decompensated cirrhosis, Hepatitis E virus, Rabbit HEV, Solid organ transplantation
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2019 16:54
Dernière modification de la notice
20/08/2019 12:38
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