Dendritic cells require T cells for functional maturation in vivo
Details
Serval ID
serval:BIB_107B426AA164
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dendritic cells require T cells for functional maturation in vivo
Journal
Immunity
ISSN
1074-7613 (Print)
Publication state
Published
Issued date
11/1999
Volume
11
Number
5
Pages
625-36
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Abstract
We examined dendritic cell (DC) status in SCID and RAG2 -/- mice to assess the influence of T cells on DC development and function in vivo. These mice have reduced numbers of DC in the epidermis and lymph nodes draining hapten-sensitized skin. Epidermal DC in these mice were defective in presenting antigen in vivo to adoptively transferred, hapten-sensitized T cells from normal mice. Likewise, draining lymph node DC were deficient in their capacity to stimulate naive T cells in vitro and in vivo. DC numbers as well as the impaired ability to present antigen in vivo, were corrected by reconstituting these animals with normal T lymphocytes, suggesting that T cells are crucial for normal DC maturation and function in vivo.
Keywords
Adoptive Transfer
Animals
Antigen Presentation
Cell Count
Cell Differentiation
DNA-Binding Proteins/deficiency/genetics
Dendritic Cells/*cytology
Dermatitis, Allergic Contact/immunology/pathology
Epidermis/immunology/pathology
Haptens/immunology
Langerhans Cells/pathology
Lymph Nodes/immunology/pathology
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Knockout
Mice, SCID
T-Lymphocyte Subsets/*physiology/transplantation
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:50
Last modification date
20/08/2019 12:37