Article: article from journal or magazin.
Cutting edge: apoptosis of superantigen-activated T cells occurs preferentially after a discrete number of cell divisions in vivo.
Journal of Immunology
Staphylococcal enterotoxins are bacterial products that display superantigen activity in vitro as well as in vivo. For instance, staphylococcal enterotoxin B (SEB) polyclonally activates T cells that bear the Vbeta8 gene segment of the TCR. SEB-activated T cells undergo a burst of proliferation that is followed by apoptosis. Using an in vivo adaptation of a fluorescent cell division monitoring technique, we show here that SEB-activated T cells divide asynchronously, and that apoptosis of superantigen-activated T cells is preferentially restricted to cells which have undergone a discrete number of cell divisions. Collectively, our data suggest that superantigen-activated T cells are programmed to undergo a fixed number of cell divisions before undergoing apoptosis. A delayed death program may provide a mechanistic compromise between effector functions and homeostasis of activated T cells.
Animals, Annexin A5/metabolism, Apoptosis/immunology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/metabolism, Cell Division/immunology, Enterotoxins/immunology, Flow Cytometry, Fluoresceins/metabolism, Lymphocyte Activation, Lymphocyte Count, Mice, Mice, Inbred BALB C, Staphylococcus aureus/immunology, Succinimides/metabolism, Superantigens/immunology, T-Lymphocytes/cytology, T-Lymphocytes/immunology
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