Cutaneous copper and zinc losses in burns.

Details

Serval ID
serval:BIB_105205DA2EAD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cutaneous copper and zinc losses in burns.
Journal
Burns
Author(s)
Berger M.M., Cavadini C., Bart A., Mansourian R., Guinchard S., Bartholdi I., Vandervale A., Krupp S., Chioléro R., Freeman J., Dirren  H.
ISSN
0305-4179
Publication state
Published
Issued date
10/1992
Peer-reviewed
Oui
Volume
18
Number
5
Pages
373-380
Language
english
Abstract
To measure the exudative cutaneous copper (Cu) and zinc (Zn) losses in burns, 10 patients, aged 36 +/- 9 years (mean +/- s.d.) with burns covering 33 +/- 10 per cent of the total body surface area, were studied from the first postburn day (D1) until D7. All intakes and losses were analysed for Cu, Zn and nitrogen (N) content. Cutaneous losses were extracted from textiles surrounding the patients. Urinary excretions were 0.12 +/- 0.06mg/24h for Cu, 0.9 +/- 0.6mg/24h for Zn, and 14.1 +/- 4.4g/24h for N. Mean daily exudative losses through wound seepage from D1 to D7 were 4.7 +/- 2.1mg/24h for Cu, 27.1 +/- 14.4mg/24h for Zn, and 8.7 +/- 3.8g/24h for N. The cumulated mean losses over 7 days were 37mg for Cu, and 212mg for Zn, representing respectively 20-40 per cent and 5-10 per cent of normal body content. Serum Cu and Zn levels were strongly depressed. The urinary Cu/N ratios correlated with clinical improvement. We conclude that the exudative Cu and Zn losses during the first week postburn contribute significantly to the increased nutrient requirements in burns.
Keywords
Adult, Alkaline Phosphatase/metabolism, Burns/metabolism, Burns/therapy, C-Reactive Protein/metabolism, Ceruloplasmin/metabolism, Copper/metabolism, Female, Humans, Male, Middle Aged, Proteins/metabolism, Skin/metabolism, Zinc/metabolism
Pubmed
Web of science
Create date
24/01/2008 16:52
Last modification date
20/08/2019 12:37
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