Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems.

Détails

Ressource 1Télécharger: 13357.full.pdf (3009.75 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_10314C79D282
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems.
Périodique
Journal of Neuroscience
Auteur(s)
Silbering A.F., Rytz R., Grosjean Y., Abuin L., Ramdya P., Jefferis G.S., Benton R.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Statut éditorial
Publié
Date de publication
2011
Volume
31
Numéro
38
Pages
13357-13375
Langue
anglais
Résumé
To sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.
Mots-clé
Animals, Animals, Genetically Modified, Biological Evolution, Drosophila/genetics, Drosophila Proteins/agonists, Drosophila Proteins/genetics, Ligands, Maze Learning/physiology, Mutation, Odors, Olfactory Pathways/anatomy & histology, Olfactory Pathways/growth & development, Olfactory Perception/genetics, Olfactory Perception/physiology, Olfactory Receptor Neurons/anatomy & histology, Olfactory Receptor Neurons/growth & development, Receptors, Ionotropic Glutamate/agonists, Receptors, Ionotropic Glutamate/genetics, Receptors, Odorant/genetics, Receptors, Odorant/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/01/2012 11:22
Dernière modification de la notice
20/08/2019 12:37
Données d'usage