Is frailty a prodromal stage of vascular dementia? Results from the Three-City Study.
Details
Serval ID
serval:BIB_0F48FA754B67
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Is frailty a prodromal stage of vascular dementia? Results from the Three-City Study.
Journal
Journal of the American Geriatrics Society
ISSN
1532-5415 (Electronic)
ISSN-L
0002-8614
Publication state
Published
Issued date
09/2012
Peer-reviewed
Oui
Volume
60
Number
9
Pages
1708-1712
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
To investigate the relationship between frailty and incident vascular dementia (VaD).
Seven-year longitudinal study.
Three-City Study, a French prospective study designed to evaluate the risk of dementia and cognitive decline attributable to vascular risk factors.
Five thousand four hundred eighty community-dwelling persons aged 65 to 95.
An expert committee established a clinical diagnosis of VaD. Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low physical activity. Participants with prior stroke or prevalent dementia at baseline were excluded from analyses. Multivariate models were used to evaluate the relationship between frailty and incident VaD.
At baseline, 6.5% of participants were classified as frail. After 7 years of follow-up, 54 persons were diagnosed with VaD, seven of whom where frail. In the proportional hazards models, frailty was marginally associated with greater risk of all types of dementia and was not associated with incident Alzheimer's disease, but frailty status was independently associated with incident VaD.
Frailty is a major risk factor for incident VaD, so its identification could contribute to better estimates of the risk of VaD in elderly adults.
Seven-year longitudinal study.
Three-City Study, a French prospective study designed to evaluate the risk of dementia and cognitive decline attributable to vascular risk factors.
Five thousand four hundred eighty community-dwelling persons aged 65 to 95.
An expert committee established a clinical diagnosis of VaD. Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low physical activity. Participants with prior stroke or prevalent dementia at baseline were excluded from analyses. Multivariate models were used to evaluate the relationship between frailty and incident VaD.
At baseline, 6.5% of participants were classified as frail. After 7 years of follow-up, 54 persons were diagnosed with VaD, seven of whom where frail. In the proportional hazards models, frailty was marginally associated with greater risk of all types of dementia and was not associated with incident Alzheimer's disease, but frailty status was independently associated with incident VaD.
Frailty is a major risk factor for incident VaD, so its identification could contribute to better estimates of the risk of VaD in elderly adults.
Keywords
Aged, Aged, 80 and over, Dementia, Vascular/diagnosis, Dementia, Vascular/epidemiology, Female, Frail Elderly, France/epidemiology, Geriatric Assessment, Humans, Longitudinal Studies, Male, Prodromal Symptoms, Proportional Hazards Models, Prospective Studies, Risk Factors
Pubmed
Web of science
Create date
23/08/2024 7:19
Last modification date
11/09/2024 7:37
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