Altered Brain Activation During Memory Retrieval Precedes and Predicts Conversion to Psychosis in Individuals at Clinical High Risk.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_0F33CF4CAE64
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Altered Brain Activation During Memory Retrieval Precedes and Predicts Conversion to Psychosis in Individuals at Clinical High Risk.
Journal
Schizophrenia bulletin
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Publication state
Published
Issued date
18/06/2019
Peer-reviewed
Oui
Volume
45
Number
4
Pages
924-933
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Memory deficits are a hallmark of psychotic disorders such as schizophrenia. However, whether the neural dysfunction underlying these deficits is present before the onset of illness and potentially predicts conversion to psychosis is unclear. In this study, we investigated brain functional alterations during memory processing in a sample of 155 individuals at clinical high risk (including 18 subjects who later converted to full psychosis) and 108 healthy controls drawn from the second phase of the North American Prodrome Longitudinal Study (NAPLS-2). All participants underwent functional magnetic resonance imaging with a paired-associate memory paradigm at the point of recruitment and were clinically followed up for approximately 2 years. We found that at baseline, subjects at high risk showed significantly higher activation during memory retrieval in the prefrontal, parietal, and bilateral temporal cortices (PFWE < .035). This effect was more pronounced in converters than nonconverters and was particularly manifested in unmedicated subjects (P < .001). The hyperactivation was significantly correlated with retrieval reaction time during scan in converters (P = .009) but not in nonconverters and controls, suggesting an exaggerated retrieval effort. These findings suggest that hyperactivation during memory retrieval may mark processes associated with conversion to psychosis, and such measures have potential as biomarkers for psychosis prediction.
Keywords
Adolescent, Adult, Association Learning/physiology, Cerebral Cortex/diagnostic imaging, Cerebral Cortex/physiopathology, Disease Progression, Female, Functional Neuroimaging, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Recall/physiology, Prodromal Symptoms, Psychotic Disorders/diagnostic imaging, Psychotic Disorders/physiopathology, Reaction Time/physiology, Risk, Young Adult, associative memory, clinical high risk, fMRI, memory retrieval, psychosis
Pubmed
Web of science
Open Access
Yes
Create date
11/01/2024 18:05
Last modification date
18/01/2024 14:58