Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.

Détails

ID Serval
serval:BIB_0F14E493E4D1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.
Périodique
Journal of Pediatric Hematology/oncology
Auteur(s)
De Ioris M.A., Fidani P., Munier F.L., Serra A., Ilari I., Popovic M.B., Natali G., Secco D.E., Cozza R.
ISSN
1536-3678 (Electronic)
ISSN-L
1077-4114
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
32
Numéro
8
Pages
e343-e345
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Trilateral retinoblastoma (TRB) is a rare condition characterized by an intracranial neuroblastic tumor associated with bilateral or unilateral retinoblastoma (RB). The outcome is almost always fatal. An 18-month-old patient with familial bilateral RB was referred for a pineal lesion detected on a screening by magnetic resonance imaging. The child, considered inoperable by 2 different neurosurgical teams, was treated with conventional chemotherapy (methotrexate, vincristine, vepeside, cyclophosphamide, and carboplatin) plus tandem transplantation (vepeside/carboplatin and thiotepa/mephalan) followed by local radiotherapy. At 80 months from the diagnosis of TRB, the patient is alive and in complete remission, with no neuropsychologic consequences. An early and aggressive treatment may improve the prognosis of TRB.
Mots-clé
Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Combined Modality Therapy, Humans, Infant, Magnetic Resonance Imaging, Pinealoma/drug therapy, Pinealoma/pathology, Prognosis, Radiation Dosage, Radiotherapy, Remission Induction, Retinoblastoma/drug therapy, Retinoblastoma/pathology
Pubmed
Web of science
Création de la notice
05/10/2010 9:22
Dernière modification de la notice
20/08/2019 12:35
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