Personnalisation de la dose, du volume et du fractionnement de la radiothérapie du sein [Individual modification of the dose, volume and fractionation of breast radiotherapy]

Détails

ID Serval
serval:BIB_0F0E75A4FBF5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Personnalisation de la dose, du volume et du fractionnement de la radiothérapie du sein [Individual modification of the dose, volume and fractionation of breast radiotherapy]
Périodique
Cancer radiotherapie
Auteur(s)
Bourgier C., Lemanski C., Draghici R., Castan F., Fenoglietto P., Bons F., Farcy-Jacquet M.P., Brengues M., Gourgou S., Ozsahin M., Azria D.
ISSN
1769-6658 (Electronic)
ISSN-L
1278-3218
Statut éditorial
Publié
Date de publication
10/2019
Peer-reviewed
Oui
Volume
23
Numéro
6-7
Pages
778-783
Langue
français
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Randomized trials demonstrated similar overall survival between mastectomy and breast-conservative surgery followed by adjuvant radiation therapy. Breast-conservative surgery, with adjuvant radiation therapy, with or without neoadjuvant systemic therapy has become the standard of care for women with early or locally advanced breast cancer. Nevertheless, certain cardiac, lung or cutaneous toxicities may alter the long-term body image and the quality of life of a limited number of patients who consider having had "overtreatment" or treatment outside the best knowledge of science. In case of low-risk breast cancer, several trials have evaluated the carcinologic outcome in absence of radiation therapy after breast-conservative surgery. Local recurrences increased in case of breast-conservative surgery alone but without impact on overall survival. Multiple debates have emerged in order to select the most appropriate evaluation criteria. Finally, a large consensus has considered that reducing local recurrences is important but with modern technologies and after identifying patients of individual radiosensitivity. Indeed, in case of a low absolute risk of local recurrence, radiation therapy techniques have been developed to allow a focal treatment especially for patients with high risk of developing late effects. This kind of compromise takes into account the reduction risk of local recurrences but also the probability of developing radiation-induced cutaneous sequelae. In the same way, for patients considered at high risk of recurrence, the huge volumes need specific techniques to better cover the targets while protecting the surrounding critic organs such as heart and lung. Intensity-modulated radiation therapy and the local high boost may help to decrease local recurrences of these more extended and aggressive diseases while considering the individual radiosensitivity that paves the way of long-term sequelae. In this article, we detail a personalized approach of breast radiation therapy considering the absolute risk of local recurrences and the probability of radiation-induced toxicity appearance.
Mots-clé
Adult, Age Factors, Aged, Breast Neoplasms/pathology, Breast Neoplasms/prevention & control, Breast Neoplasms/radiotherapy, Dose Fractionation, Radiation, Female, Humans, Middle Aged, Neoplasm Recurrence, Local/prevention & control, Organs at Risk/radiation effects, Precision Medicine/methods, Radiation Injuries/etiology, Radiation Tolerance, Risk Assessment, Tumor Burden, Breast, Effets indésirables, Individual radiosensitivity, Late effects, Radiosensibilité, Radiotherapy, Radiothérapie, Sein
Pubmed
Web of science
Création de la notice
18/08/2019 14:42
Dernière modification de la notice
28/01/2020 6:20
Données d'usage