A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides.

Détails

ID Serval
serval:BIB_0EF608CDF7F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides.
Périodique
FEBS Letters
Auteur(s)
Corona M., Gurrola G.B., Merino E., Cassulini R.R., Valdez-Cruz N.A., García B., Ramírez-Domínguez M.E., Coronas F.I., Zamudio F.Z., Wanke E., Possani L.D.
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
532
Numéro
1-2
Pages
121-126
Langue
anglais
Résumé
Twenty-three novel sequences similar to Ergtoxin (ErgTx) were obtained by direct sequencing of peptides or deduced from gene cloned using cDNAs of venomous glands of Centruroides (C.) elegans, C. exilicauda, C. gracilis, C. limpidus limpidus, C. noxius and C. sculpturatus. These peptides have from 42 to 47 amino acid residues cross-linked by four disulfide bridges. They share sequence similarities (60-98% compared with ErgTx1) and were shown to block ERG K(+)-channels of F-11 clone (N18TG-2xrat DRG) cultured cells. An unrooted phylogenetic tree analysis of these peptides showed that they conform at least five different subfamilies, of which three are novel subfamilies.
Mots-clé
Amino Acid Sequence, Animals, Cloning, Molecular, Electric Conductivity, Genes, Mice, Molecular Sequence Data, Peptides/genetics, Peptides/pharmacology, Phylogeny, Potassium Channel Blockers/classification, Potassium Channel Blockers/pharmacology, Potassium Channels/physiology, Scorpion Venoms/classification, Scorpion Venoms/genetics, Sequence Alignment, Tumor Cells, Cultured
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2008 12:51
Dernière modification de la notice
20/08/2019 13:35
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