Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Allergo-immunologie. 1. Nouveaux concepts de traitement du lupus erythemateux dissemine. [New concepts for the therapy of systemic lupus erythematosus]
Revue Médicale Suisse
English Abstract Journal Article Review
Immediate, short- and long-term adverse events of classical immunosuppressor drugs strongly stimulate novel, but less toxic approaches. Combined or sequential use of cyclophosphamide, mycophenolate mofetil and/ or azathioprine should improve clinical tolerance and avoid severe adverse events (infections, infertility, amenorrhea), regularly associated to long term therapies with classical immunosuppressive schemes. Among novel developments based on biologicals, the anti-CD20 monoclonal antibody rituximab (anti-B cells) appears encouraging in open studies, in association or not with cyclophosphamide, and is generally well tolerated. Further information is expected from the inhibitor of T cell/B cell co-stimulation CTLA4-Ig, or from strategies aiming to inhibit key cytokines in SLE pathogenesis such as interferon-alpha, IL-1 or IL-6.
B-Lymphocytes/drug effects Humans Immunosuppressive Agents/*therapeutic use Lupus Erythematosus, Systemic/*drug therapy
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