Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging.

Détails

Ressource 1Télécharger: 26236626_BIB_0EE6C652B26C.pdf (1779.85 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_0EE6C652B26C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging.
Périodique
Neuroimage. Clinical
Auteur(s)
Lemkaddem A., Daducci A., Kunz N., Lazeyras F., Seeck M., Thiran J.P., Vulliémoz S.
ISSN
2213-1582 (Electronic)
ISSN-L
2213-1582
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
5
Pages
349-358
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: epublish
Résumé
Focal epilepsy is increasingly recognized as the result of an altered brain network, both on the structural and functional levels and the characterization of these widespread brain alterations is crucial for our understanding of the clinical manifestation of seizure and cognitive deficits as well as for the management of candidates to epilepsy surgery. Tractography based on Diffusion Tensor Imaging allows non-invasive mapping of white matter tracts in vivo. Recently, diffusion spectrum imaging (DSI), based on an increased number of diffusion directions and intensities, has improved the sensitivity of tractography, notably with respect to the problem of fiber crossing and recent developments allow acquisition times compatible with clinical application. We used DSI and parcellation of the gray matter in regions of interest to build whole-brain connectivity matrices describing the mutual connections between cortical and subcortical regions in patients with focal epilepsy and healthy controls. In addition, the high angular and radial resolution of DSI allowed us to evaluate also some of the biophysical compartment models, to better understand the cause of the changes in diffusion anisotropy. Global connectivity, hub architecture and regional connectivity patterns were altered in TLE patients and showed different characteristics in RTLE vs LTLE with stronger abnormalities in RTLE. The microstructural analysis suggested that disturbed axonal density contributed more than fiber orientation to the connectivity changes affecting the temporal lobes whereas fiber orientation changes were more involved in extratemporal lobe changes. Our study provides further structural evidence that RTLE and LTLE are not symmetrical entities and DSI-based imaging could help investigate the microstructural correlate of these imaging abnormalities.
Mots-clé
Adolescent, Adult, Brain/pathology, Connectome/methods, Diffusion Tensor Imaging/methods, Epilepsy, Temporal Lobe/pathology, Female, Humans, Image Interpretation, Computer-Assisted/methods, Male, Middle Aged, Nerve Net/pathology, Neural Pathways/pathology, Reproducibility of Results, Sensitivity and Specificity, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
07/03/2016 19:45
Dernière modification de la notice
08/05/2019 14:27
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