Inflammasomes: mechanism of assembly, regulation and signalling.

Détails

ID Serval
serval:BIB_0EE04AC88A5C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Inflammasomes: mechanism of assembly, regulation and signalling.
Périodique
Nature reviews. Immunology
Auteur(s)
Broz P., Dixit V.M.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
16
Numéro
7
Pages
407-420
Langue
anglais
Résumé
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders. In this Review, we discuss the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammasome assembly, signalling and regulation.

Mots-clé
Animals, Humans, Inflammasomes/physiology, Signal Transduction/immunology
Pubmed
Web of science
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/08/2019 13:35
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