Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis.

Détails

Ressource 1Télécharger: BIB_0E64C2E502A9.P001.pdf (1000.10 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_0E64C2E502A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impaired fornix-hippocampus integrity is linked to peripheral glutathione peroxidase in early psychosis.
Périodique
Translational psychiatry
Auteur(s)
Baumann P.S., Griffa A., Fournier M., Golay P., Ferrari C., Alameda L., Cuenod M., Thiran J.P., Hagmann P., Do K.Q., Conus P.
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Statut éditorial
Publié
Date de publication
26/07/2016
Peer-reviewed
Oui
Volume
6
Numéro
7
Pages
e859
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Several lines of evidence implicate the fornix-hippocampus circuit in schizophrenia. In early-phase psychosis, this circuit has not been extensively investigated and the underlying mechanisms affecting the circuit are unknown. The hippocampus and fornix are vulnerable to oxidative stress at peripuberty in a glutathione (GSH)-deficient animal model. The purposes of the current study were to assess the integrity of the fornix-hippocampus circuit in early-psychosis patients (EP), and to study its relationship with peripheral redox markers. Diffusion spectrum imaging and T1-weighted magnetic resonance imaging (MRI) were used to assess the fornix and hippocampus in 42 EP patients compared with 42 gender- and age-matched healthy controls. Generalized fractional anisotropy (gFA) and volumetric properties were used to measure fornix and hippocampal integrity, respectively. Correlation analysis was used to quantify the relationship of gFA in the fornix and hippocampal volume, with blood GSH levels and glutathione peroxidase (GPx) activity. Patients compared with controls exhibited lower gFA in the fornix as well as smaller volume in the hippocampus. In EP, but not in controls, smaller hippocampal volume was associated with high GPx activity. Disruption of the fornix-hippocampus circuit is already present in the early stages of psychosis. Higher blood GPx activity is associated with smaller hippocampal volume, which may support a role of oxidative stress in disease mechanisms.

Mots-clé
Adult, Anisotropy, Bipolar Disorder/blood, Bipolar Disorder/diagnostic imaging, Bipolar Disorder/pathology, Case-Control Studies, Depressive Disorder, Major/blood, Depressive Disorder, Major/diagnostic imaging, Depressive Disorder, Major/pathology, Diffusion Tensor Imaging, Female, Fornix, Brain/diagnostic imaging, Fornix, Brain/pathology, Glutathione/blood, Glutathione Peroxidase/blood, Hippocampus/diagnostic imaging, Hippocampus/pathology, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Organ Size, Oxidative Stress, Psychotic Disorders/blood, Psychotic Disorders/diagnostic imaging, Psychotic Disorders/pathology, Schizophrenia/blood, Schizophrenia/diagnostic imaging, Schizophrenia/pathology, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/04/2016 8:55
Dernière modification de la notice
20/08/2019 13:35
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