Stress-induced changes of circulating neuropeptide Y in the rat: comparison with catecholamines

Détails

ID Serval
serval:BIB_0DE8F7D02D55
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Stress-induced changes of circulating neuropeptide Y in the rat: comparison with catecholamines
Périodique
Regulatory Peptides
Auteur(s)
Castagne  V., Corder  R., Gaillard  R., Mormede  P.
ISSN
0167-0115 (Print)
Statut éditorial
Publié
Date de publication
10/1987
Volume
19
Numéro
1-2
Pages
55-63
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Circulating concentrations of neuropeptide Y-like immunoreactivity (NPY), noradrenaline (NA) and adrenaline (AD) were measured in conscious, chronically catheterized rats submitted to various stress protocols. Basal plasma levels of NPY, NA and AD (194 +/- 52 fmol/ml, 0.90 +/- 0.11 pmol/ml and 0.52 +/- 0.07 pmol/ml) were increased by handling (+132%, +76% and +629%, respectively) and rose further during electric shock treatment. Adrenalectomy resulted in the complete disappearance of circulating adrenaline but did not alter either control or stress values of noradrenaline. In comparison circulating levels of NPY were reduced, but not significantly in adrenalectomized animals. Insulin stress induced a large increase in plasma AD levels and cold stress induced an increase in plasma NA levels, without any parallel change in NPY concentrations. These results demonstrate that NPY, which is colocalized with catecholamines in the peripheral nervous systems, is also released during stress responses and that its release parallels more closely changes in circulating NA than AD. Furthermore, stress-induced changes in circulating NPY-like immunoreactivity do not originate from the adrenal gland but mainly from the peripheral nervous system, and the release of NPY is dependent upon the nature of the stimulus.
Mots-clé
Adrenalectomy Animals Electroshock Epinephrine/*blood Handling (Psychology) Insulin Male Neuropeptide Y/*blood Norepinephrine/*blood Radioimmunoassay Rats Rats, Inbred Strains Stress/*physiopathology Stress, Psychological/*physiopathology
Pubmed
Web of science
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
03/03/2018 13:41
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