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Is the coiled body involved in nucleolar functions?
Experimental Cell Research
Date de publication
Coiled bodies (CBs) are structural constituents observed in nuclei of most eukaryotic cells. They usually occur in the nucleoplasm as well as in contact with the nucleolar surface. In this work we studied the hepatocyte nuclei of hibernating dormice in order to investigate possible modifications of CBs along the seasonal cycle. CBs were abundant during hibernation and rapidly disappeared upon arousal from hibernation. Moreover, CBs were frequently found to be integrated into the nucleolar body. Immunocytochemical analyses showed that CBs contain nucleoplasmic as well as nucleolar RNA-processing factors, suggesting an "ambiguous" role for this organelle in the nuclear functions.
Animals, Antibodies, Monoclonal, Cell Nucleolus/metabolism, Cell Nucleolus/ultrastructure, Chromosomal Proteins, Non-Histone/metabolism, Hibernation, Liver/metabolism, Liver/ultrastructure, Microscopy, Immunoelectron, Nuclear Proteins/immunology, Nuclear Proteins/metabolism, RNA Precursors/metabolism, Ribonucleoproteins, Small Nuclear/metabolism, Rodentia
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