Selective GABAergic control of higher-order thalamic relays.

Details

Serval ID
serval:BIB_0DC03097BA2D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Selective GABAergic control of higher-order thalamic relays.
Journal
Neuron
Author(s)
Bokor H., Frère S.G., Eyre M.D., Slézia A., Ulbert I., Lüthi A., Acsády L.
ISSN
0896-6273
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
45
Number
6
Pages
929-940
Language
english
Abstract
GABAergic signaling is central to the function of the thalamus and has been traditionally attributed primarily to the nucleus reticularis thalami (nRT). Here we present a GABAergic pathway, distinct from the nRT, that exerts a powerful inhibitory effect selectively in higher-order thalamic relays of the rat. Axons originating in the anterior pretectal nucleus (APT) innervated the proximal dendrites of relay cells via large GABAergic terminals with multiple release sites. Stimulation of the APT in an in vitro slice preparation revealed a GABA(A) receptor-mediated, monosynaptic IPSC in relay cells. Activation of presumed single APT fibers induced rebound burst firing in relay cells. Different APT neurons recorded in vivo displayed fast bursting, tonic, or rhythmic firing. Our data suggest that selective extrareticular GABAergic control of relay cell activity will result in effective, state-dependent gating of thalamocortical information transfer in higher-order but not in first-order relays.
Keywords
Action Potentials, Afferent Pathways, Animals, Biotin, Cell Shape, Dendrites, Dextrans, Electric Stimulation, Immunohistochemistry, Male, Mesencephalon, Microscopy, Electron, Transmission, Neural Inhibition, Organ Culture Techniques, Parvalbumins, Phytohemagglutinins, Presynaptic Terminals, Rats, Rats, Wistar, Receptors, GABA-A, Synaptic Transmission, Thalamus, gamma-Aminobutyric Acid
Pubmed
Web of science
Open Access
Yes
Create date
26/02/2009 14:41
Last modification date
20/08/2019 12:34
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