Selective GABAergic control of higher-order thalamic relays.

Détails

ID Serval
serval:BIB_0DC03097BA2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Selective GABAergic control of higher-order thalamic relays.
Périodique
Neuron
Auteur(s)
Bokor H., Frère S.G., Eyre M.D., Slézia A., Ulbert I., Lüthi A., Acsády L.
ISSN
0896-6273
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
45
Numéro
6
Pages
929-940
Langue
anglais
Résumé
GABAergic signaling is central to the function of the thalamus and has been traditionally attributed primarily to the nucleus reticularis thalami (nRT). Here we present a GABAergic pathway, distinct from the nRT, that exerts a powerful inhibitory effect selectively in higher-order thalamic relays of the rat. Axons originating in the anterior pretectal nucleus (APT) innervated the proximal dendrites of relay cells via large GABAergic terminals with multiple release sites. Stimulation of the APT in an in vitro slice preparation revealed a GABA(A) receptor-mediated, monosynaptic IPSC in relay cells. Activation of presumed single APT fibers induced rebound burst firing in relay cells. Different APT neurons recorded in vivo displayed fast bursting, tonic, or rhythmic firing. Our data suggest that selective extrareticular GABAergic control of relay cell activity will result in effective, state-dependent gating of thalamocortical information transfer in higher-order but not in first-order relays.
Mots-clé
Action Potentials, Afferent Pathways, Animals, Biotin, Cell Shape, Dendrites, Dextrans, Electric Stimulation, Immunohistochemistry, Male, Mesencephalon, Microscopy, Electron, Transmission, Neural Inhibition, Organ Culture Techniques, Parvalbumins, Phytohemagglutinins, Presynaptic Terminals, Rats, Rats, Wistar, Receptors, GABA-A, Synaptic Transmission, Thalamus, gamma-Aminobutyric Acid
Pubmed
Web of science
Création de la notice
26/02/2009 15:41
Dernière modification de la notice
03/03/2018 13:40
Données d'usage