Immunotherapy for ovarian cancer: recent advances and perspectives.

Details

Serval ID
serval:BIB_0D9F55B9E77A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immunotherapy for ovarian cancer: recent advances and perspectives.
Journal
Current opinion in oncology
Author(s)
Zsiros E., Tanyi J., Balint K., Kandalaft L.E.
ISSN
1531-703X (Electronic)
ISSN-L
1040-8746
Publication state
Published
Issued date
09/2014
Peer-reviewed
Oui
Volume
26
Number
5
Pages
492-500
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Epithelial ovarian cancer is the most frequent cause of gynecologic cancer-related mortality in women, and prognosis for patients with recurrent or metastatic disease is extremely poor. Therefore, there is an enormous unmet need for the development of novel therapies in this indication. Although surgery and chemotherapy can improve survival rates, it is necessary to integrate alternative strategies, such as immunotherapy to improve the outcomes for patients with advanced ovarian cancer.
We will discuss the rationale of immunotherapy and some of the mechanisms of immunogenicity in ovarian cancer. We will highlight current results with cancer vaccines, adoptive T-cell therapy and immunomodulatory agents and will summarize the immune effects of selected chemotherapeutic agents, radiotherapy and recent results with combinatorial approaches in this disease setting. We will also discuss recent and potential future therapeutic interventions that might circumvent tumor-mediated immunosuppression.
Dramatic increase in the number of immunotherapy clinical trials was seen in the past decade with promising results in enhancing antitumor immune response and cancer vaccine efficacy. The future challenge for immunotherapy against ovarian cancer is to use a combinatorial approach to test rational, potentially synergistic immunotherapy combinations that can induce efficient antitumor immunity and prolong patients' survival.

Keywords
Female, Humans, Immunotherapy, Ovarian Neoplasms/drug therapy, Ovarian Neoplasms/immunology, Ovarian Neoplasms/radiotherapy, Ovarian Neoplasms/therapy
Pubmed
Web of science
Create date
09/02/2018 15:21
Last modification date
20/08/2019 12:34
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