Differential monocular vs. binocular pupil responses from melanopsin-based photoreception in patients with anterior ischemic optic neuropathy.

Détails

Ressource 1Télécharger: BIB_0D41364EDD3B.P001.pdf (921.35 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_0D41364EDD3B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Differential monocular vs. binocular pupil responses from melanopsin-based photoreception in patients with anterior ischemic optic neuropathy.
Périodique
Scientific Reports
Auteur(s)
Tsika C., Crippa S.V., Kawasaki A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
5
Pages
10780
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
We examined the effect of anterior ischemic optic neuropathy (AION) on the activity of intrinsically photosensitive retinal ganglion cells (ipRGCs) using the pupil as proxy. Eighteen patients with AION (10 unilateral, 8 bilateral) and 29 age-matched control subjects underwent chromatic pupillometry. Red and blue light stimuli increasing in 0.5 log steps were presented to each eye independently under conditions of dark and light adaptation. The recorded pupil contraction was plotted against stimulus intensity to generate scotopic and photopic response curves for assessment of synaptically-mediated ipRGC activity. Bright blue light stimuli presented monocularly and binocularly were used for melanopsin activation. The post-stimulus pupil size (PSPS) at the 6th second following stimulus offset was the marker of intrinsic ipRGC activity. Finally, questionnaires were administered to assess the influence of ipRGCs on sleep. The pupil response and PSPS to all monocularly-presented light stimuli were impaired in AION eyes, indicating ipRGC dysfunction. To binocular light stimulation, the PSPS of AION patients was similar to that of controls. There was no difference in the sleep habits of the two groups. Thus after ischemic injury to one or both optic nerves, the summated intrinsic ipRGC activity is preserved when both eyes receive adequate light exposure.
Mots-clé
Adult, Aged, Case-Control Studies, Female, Humans, Light, Male, Middle Aged, Optic Neuropathy, Ischemic/metabolism, Optic Neuropathy, Ischemic/physiopathology, Photoreceptor Cells/metabolism, Photoreceptor Cells/pathology, Pupil/physiology, Retinal Ganglion Cells/metabolism, Retinal Ganglion Cells/pathology, Rod Opsins/physiology, Sleep/physiology, Surveys and Questionnaires, Vision, Binocular, Vision, Monocular
Pubmed
Web of science
Création de la notice
25/06/2015 12:02
Dernière modification de la notice
19/03/2018 10:50
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