Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls.

Détails

Ressource 1Télécharger: BIB_0D21BD8C5A58.P001.pdf (970.58 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_0D21BD8C5A58
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls.
Périodique
Scientific Reports
Auteur(s)
Münch M., Léon L., Collomb S., Kawasaki A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
10/2015
Peer-reviewed
Oui
Volume
5
Pages
15185
Langue
anglais
Résumé
This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on non-visual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic neuropathy (n = 11) or glaucoma (n = 11). We measured melatonin suppression, subjective sleepiness and cognitive functions in response to bright light exposure in the evening. We also quantified the post-illumination pupil response to a blue light stimulus. All results were compared to age-matched controls (n = 22). Both groups of patients showed similar melatonin suppression when compared to their controls. Greater melatonin suppression was intra-individually correlated to larger post-illumination pupil response in patients and controls. Only the glaucoma patients demonstrated a relative attenuation of their pupil response. In addition, they were sleepier with slower reaction times during nocturnal light exposure. In conclusion, glaucomatous, but not hereditary, optic neuropathy is associated with reduced acute light effects. At mild to moderate stages of disease, this is detected only in the pupil function and not in responses conveyed via the retinohypothalamic tract such as melatonin suppression.
Mots-clé
Adult, Case-Control Studies, Female, Glaucoma/diagnosis, Glaucoma/metabolism, Humans, Light, Male, Melatonin/metabolism, Middle Aged, Optic Nerve Diseases/diagnosis, Optic Nerve Diseases/metabolism, Psychomotor Performance, Pupil, Retinal Ganglion Cells/metabolism, Rod Opsins/metabolism, Saliva/metabolism, Signal Transduction, Sleep/radiation effects, Vision, Ocular, Visual Acuity, Visual Fields, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/02/2016 17:32
Dernière modification de la notice
08/05/2019 14:21
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