Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_0D21BD8C5A58
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls.
Journal
Scientific Reports
Author(s)
Münch M., Léon L., Collomb S., Kawasaki A.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
10/2015
Peer-reviewed
Oui
Volume
5
Pages
15185
Language
english
Abstract
This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on non-visual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic neuropathy (n = 11) or glaucoma (n = 11). We measured melatonin suppression, subjective sleepiness and cognitive functions in response to bright light exposure in the evening. We also quantified the post-illumination pupil response to a blue light stimulus. All results were compared to age-matched controls (n = 22). Both groups of patients showed similar melatonin suppression when compared to their controls. Greater melatonin suppression was intra-individually correlated to larger post-illumination pupil response in patients and controls. Only the glaucoma patients demonstrated a relative attenuation of their pupil response. In addition, they were sleepier with slower reaction times during nocturnal light exposure. In conclusion, glaucomatous, but not hereditary, optic neuropathy is associated with reduced acute light effects. At mild to moderate stages of disease, this is detected only in the pupil function and not in responses conveyed via the retinohypothalamic tract such as melatonin suppression.
Keywords
Adult, Case-Control Studies, Female, Glaucoma/diagnosis, Glaucoma/metabolism, Humans, Light, Male, Melatonin/metabolism, Middle Aged, Optic Nerve Diseases/diagnosis, Optic Nerve Diseases/metabolism, Psychomotor Performance, Pupil, Retinal Ganglion Cells/metabolism, Rod Opsins/metabolism, Saliva/metabolism, Signal Transduction, Sleep/radiation effects, Vision, Ocular, Visual Acuity, Visual Fields, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
04/02/2016 16:32
Last modification date
20/08/2019 12:34
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