Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution

Détails

ID Serval
serval:BIB_0D20366C5661
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
Périodique
Journal of Experimental Medicine
Auteur(s)
Healy  F., Drouet  C., Romero  P., Jaulin  C., Maryanski  J. L.
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
12/1991
Volume
174
Numéro
6
Pages
1657-60
Notes
Journal Article --- Old month value: Dec 1
Résumé
We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.
Mots-clé
Amino Acid Sequence Animals H-2 Antigens/*immunology Immunization Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data Peptides/*immunology Structure-Activity Relationship T-Lymphocytes, Cytotoxic/immunology Tyrosine
Pubmed
Web of science
Création de la notice
28/01/2008 12:27
Dernière modification de la notice
03/03/2018 13:39
Données d'usage