Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_0CFF7786C7C7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.
Périodique
European journal of epidemiology
Auteur(s)
Castagné R., Garès V., Karimi M., Chadeau-Hyam M., Vineis P., Delpierre C., Kelly-Irving M.
Collaborateur(s)
Lifepath Consortium
Contributeur(s)
Alenius H., Avendano M., Baltar V., Bartley M., Barros H., Bochud M., Carmeli C., Carra L., Costa G., Courtin E., Donkin A., D'Errico A., Dugue P.A., Elliott P., Fiorito G., Fraga S., Gandini M., Giles G., Goldberg M., Greco D., Hodge A., Karisola P., Kivimaki M., Laine J., Lang T., Layte R., Lepage B., Mackenbach J., Marmot M., de Mestral C., McCrory C., Milne R., Muennig P., Nusselder W., Petrovic D., Polidoro S., Preisig M., Raitakari O., Ribeiro A.I., Ricceri F., Reinhard E., Robinson O., Valverde J.R., Satolli R., Severi G., Stringhini S., Tieulent J., Vaccarella S., Vergnaud A.C., Vollenweider P., Zins M.
ISSN
1573-7284 (Electronic)
ISSN-L
0393-2990
Statut éditorial
Publié
Date de publication
05/2018
Peer-reviewed
Oui
Volume
33
Numéro
5
Pages
441-458
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults. Specifically, we interrogate the hypothesis of a cumulative biological risk (allostatic load) reflecting 4 physiological systems potentially predicting future risk of death (N = 132). AL was defined using 14 biomarkers assayed in blood from a biosample collected at 44 years of age. Cox proportional hazard regression analysis revealed that higher allostatic load at 44 years old was a significant predictor of mortality 11 years later [HR = 3.56 (2.3 to 5.53)]. We found that this relationship was not solely related to early-life SEP, adverse childhood experiences and young adulthood health status, behaviours and SEP [HR = 2.57 (1.59 to 4.15)]. Regarding the ability of each physiological system and biomarkers to predict future death, our results suggest that the cumulative measure was advantageous compared to evaluating each physiological system sub-score and biomarker separately. Our findings add some evidence of a biological embodiment in response to stress which ultimately affects mortality.
Mots-clé
Allostatic load, Cohort study, Health behaviours, Mortality, Social environment
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2019 15:23
Dernière modification de la notice
20/08/2019 13:34
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