mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders.

Détails

ID Serval
serval:BIB_0CE5BB9CB8CC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders.
Périodique
Current opinion in neurobiology
Auteur(s)
Petrelli F., Bezzi P.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Statut éditorial
Publié
Date de publication
02/2018
Peer-reviewed
Oui
Volume
48
Pages
139-145
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Astrocytes, the largest glial population in human and murine brains, are crucial to the regulation of synaptic connectivity. During the first three weeks of postnatal development, immature astrocytes express mGlu5 and expands several fold while undergoing a transition towards their mature phase. Although mGlu5-mediated signalling in astrocyte functions has been extensively studied in the last decades, whether this signalling is implicated in the mechanisms governing their development, as well as the effects of dysregulated astrocytic development on neurodevelopmental disorders, are still unclear. The aim of this review is to examine what is known about the mGlu5-mediated signalling in the developing astrocytes and its possible contribution to the pathophysiology of autism spectrum disorders.
Mots-clé
Animals, Astrocytes/metabolism, Autism Spectrum Disorder/genetics, Autism Spectrum Disorder/pathology, Humans, Receptor, Metabotropic Glutamate 5/physiology, Signal Transduction/physiology
Pubmed
Web of science
Création de la notice
22/01/2018 10:29
Dernière modification de la notice
26/03/2019 7:26
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