Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.
Details
Serval ID
serval:BIB_0CE036721ED1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.
Journal
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
ISSN
1435-702X (Electronic)
ISSN-L
0721-832X
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Publication Status: aheadofprint
Abstract
To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.
A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA <sub>AT</sub> ), start (FA <sub>startLF</sub> ) and end (FA <sub>endLF</sub> ) of laminar flow, and arterial time (ICGA <sub>AT</sub> ), respectively. OCT angiography VDs were superficial (VD <sub>SCP</sub> ) and deep (VD <sub>DCP</sub> ) RCPs and CC (VD <sub>CC</sub> ) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.
177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VD <sub>SCP</sub> and VD <sub>DCP</sub> were significantly inversely correlated with FA <sub>AT</sub> , FA <sub>startLF</sub> and FA <sub>endLF</sub> likewise VD <sub>CC</sub> with ICGA <sub>AT</sub> . Correlations were stronger in patients without CVR than with CVR. CVR, FA <sub>AT</sub> , FA <sub>startLF</sub> and FA <sub>endLF</sub> were more strongly correlated with VD <sub>DCP</sub> than VD <sub>SCP</sub> . FA <sub>AT</sub> , FA <sub>startLF</sub> and FA <sub>endLF</sub> significantly impacted VD <sub>SCP</sub> and VD <sub>DCP</sub> , likewise ICGA <sub>AT</sub> impacted VD <sub>DCP</sub> . VD <sub>DCP</sub> was most strongly impacted by FA <sub>AT</sub> and FA <sub>startLF</sub> .
Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA <sub>AT</sub> ), start (FA <sub>startLF</sub> ) and end (FA <sub>endLF</sub> ) of laminar flow, and arterial time (ICGA <sub>AT</sub> ), respectively. OCT angiography VDs were superficial (VD <sub>SCP</sub> ) and deep (VD <sub>DCP</sub> ) RCPs and CC (VD <sub>CC</sub> ) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.
177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VD <sub>SCP</sub> and VD <sub>DCP</sub> were significantly inversely correlated with FA <sub>AT</sub> , FA <sub>startLF</sub> and FA <sub>endLF</sub> likewise VD <sub>CC</sub> with ICGA <sub>AT</sub> . Correlations were stronger in patients without CVR than with CVR. CVR, FA <sub>AT</sub> , FA <sub>startLF</sub> and FA <sub>endLF</sub> were more strongly correlated with VD <sub>DCP</sub> than VD <sub>SCP</sub> . FA <sub>AT</sub> , FA <sub>startLF</sub> and FA <sub>endLF</sub> significantly impacted VD <sub>SCP</sub> and VD <sub>DCP</sub> , likewise ICGA <sub>AT</sub> impacted VD <sub>DCP</sub> . VD <sub>DCP</sub> was most strongly impacted by FA <sub>AT</sub> and FA <sub>startLF</sub> .
Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.
Keywords
Choriocapillaris, Fluorescein angiography, Indocyanine angiography, OCT angiography, Retinal capillary, Retinal imaging
Pubmed
Web of science
Open Access
Yes
Create date
05/08/2024 15:51
Last modification date
20/08/2024 6:22
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