PD-L1 expression in PitNETs: Correlations with the 2022 WHO classification.

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Serval ID
serval:BIB_0CDD946F5851
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
PD-L1 expression in PitNETs: Correlations with the 2022 WHO classification.
Journal
Brain & spine
Author(s)
Harel E., Hewer E., La Rosa S., Brouland J.P., Pitteloud N., Santoni F., Brunner M., Daniel R.T., Messerer M., Cossu G.
ISSN
2772-5294 (Electronic)
ISSN-L
2772-5294
Publication state
Published
Issued date
2025
Peer-reviewed
Oui
Volume
5
Pages
104171
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
and research question: Prognostic factors to predict the behavior of pituitary neuroendocrine tumors (PitNET) are scarce. PD-L1 expression was associated with prognosis in other neuroendocrine neoplasms and we analyzed PD-L1 expression in PitNET, according to the 2022 WHO classification.
A retrospective analysis was performed. Immunohistochemistry was used to define PD-L1 expression, which was quantified as TPS (tumor proportion score). The primary outcome was to assess the correlation between PD-L1 expression and transcription factors (TF), namely T-pit, Pit-1, SF-1 and GATA-3. As secondary outcomes, we evaluated the association between PD-L1 expression and proliferation indexes.
Eighty-eight patients were included. The largest group belonged to the SF-1-lineage (48%), followed by tumors of the Pit-1 lineage (32%) and T-pit lineage (17%). PD-L1 expression was associated with Pit-1 expression (p < 0.001) and with the somatotroph, lactotroph and mammosomatotroph subgroups. A TPS ⩾35% showed a 100% sensitivity for the mammosomatotroph subtype, while the optimal cut-off point was 20% for somatotroph and 15% for lactotroph tumors. PD-L1 expression was negatively associated with SF-1 and GATA3 expression(p < 0.001), with an optimal cut-point ≤5%. No association was found between PD-L1 expression and immunohistochemical proliferative factors but PD-L1 expression was associated with female sex and a younger age at diagnosis.
PD-L1 expression was associated with PIT-1 lineage, while it was downregulated in SF-1-lineage tumors. No correlation was found with proliferative factors. The role of PD-L1 expression in determining the biological behavior of PitNET remains debated and larger studies are necessary to further confirm these findings.
Keywords
2022 WHO classification of PitNETs, PD-L1, Pit-NETs, Pituitary adenoma, Pituitary neuroendocrine tumors, Transcription factors
Pubmed
Open Access
Yes
Create date
24/01/2025 14:17
Last modification date
25/02/2025 7:09
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