Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.

Détails

ID Serval
serval:BIB_0CD1A282E7A5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.
Périodique
Faseb Journal
Auteur(s)
Wahli W., Martinez E.
ISSN
0892-6638[print], 0892-6638[linking]
Statut éditorial
Publié
Date de publication
06/1991
Volume
5
Numéro
9
Pages
2243-2249
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
The nuclear hormone receptor superfamily is characterized by an impressive functional diversity of its members despite a remarkable overall structural unity. A variety of ligands bind specifically to them and these receptors control gene networks that have profound effects on growth, development, and homeostasis. The ligand-receptor complexes recognize transcriptional enhancer DNA sequences, the hormone response elements, resulting in induction or repression of gene activity. The similarity between all these hormone response enhancer elements, as well as between the receptors themselves, indicates a conserved general strategy for the hormonal control of transcription by steroids. The activated receptors bind to responsive promoters and most likely mediate the assembly of stage- and tissue-specific transcription factor complexes that stimulate or inhibit gene expression.
Mots-clé
Animals, Base Sequence, Gene Expression Regulation, Molecular Sequence Data, Multigene Family, Receptors, Steroid/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 17:04
Dernière modification de la notice
03/03/2018 13:38
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