Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients

Détails

ID Serval
serval:BIB_0CBCAD328F2F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients
Périodique
Bone and Mineral
Auteur(s)
Zerwekh  J. E., Antich  P. P., Sakhaee  K., Prior  J., Gonzales  J., Gottschalk  F., Pak  C. Y.
ISSN
0169-6009
Statut éditorial
Publié
Date de publication
07/1992
Volume
18
Numéro
1
Pages
65-76
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Résumé
We evaluated the effects of intermittent slow-release sodium fluoride (SRNaF) and continuous calcium citrate therapy on cortical bone histology, reflection ultrasound velocity (material strength) and back-scattered electron image analysis (BEI) in 26 osteoporotic patients before and following therapy. All measurements were made on transiliac crest bone biopsies obtained before and following 2 years of therapy in each patient. For all 26 patients there were no significant changes in cortical bone histomorphometric parameters. In 15 patients in whom bone material quality was assessed by reflection ultrasound, there was no change in velocity (4000 +/- 227 SD to 4013 +/- 240 m/s). BEI disclosed no mineralization defects or the presence of woven bone. Mean atomic number (density) of bone increased slightly, but significantly (9.261 +/- 0.311 to 9.457 +/- 0.223, P = 0.031). While these changes are less marked than those observed for cancellous bone, they indicate that this form of therapy does not adversely affect cortical bone remodelling.
Mots-clé
Adult Aged Bone Density/drug effects Bone Remodeling/*drug effects Citrates/administration & dosage/*therapeutic use Citric Acid Delayed-Action Preparations Drug Therapy, Combination Female Humans Male Middle Aged Osteoporosis/*drug therapy/pathology/physiopathology Osteoporosis, Postmenopausal/drug therapy/pathology/physiopathology Sodium Fluoride/administration & dosage/*therapeutic use Spinal Fractures
Pubmed
Web of science
Création de la notice
29/01/2008 17:38
Dernière modification de la notice
03/03/2018 13:38
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