Article: article from journal or magazin.
The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion
PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't
Interaction with antigen-presenting accessory cells is thought to be an important step in B-cell activation, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells
Amino Acid Sequence/Antigens,CD/genetics/immunology/Antigens,CD22/Antigens,Differentiation,B-Lymphocyte/B-Lymphocytes/Base Sequence/Cell Adhesion/Cell Adhesion Molecules/Cloning,Molecular/Erythrocytes/Immunosorbent Techniques/Lectins/Molecular Sequence Data/Molecular Weight/Monocytes/Myelin Proteins/Myelin-Associated Glycoprotein/Nucleic Acid Hybridization/Rna/analysis/Receptors,Antigen,B-Cell/Recombinant Proteins/Rosette Formation/Sequence Homology,Nucleic Acid/Transfection/Tumor Cells,Cultured/Research
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