Impact of disease and treatments on growth and puberty of pediatric patients with inflammatory bowel disease.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_0C73C867D65E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Impact of disease and treatments on growth and puberty of pediatric patients with inflammatory bowel disease.
Périodique
Digestion
Auteur(s)
Ezri J., Marques-Vidal P., Nydegger A.
ISSN
1421-9867 (Electronic)
ISSN-L
0012-2823
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
85
Numéro
4
Pages
308-319
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Growth retardation, associated with delayed puberty, is a frequent feature in pediatric patients with inflammatory bowel disease (IBD), especially with Crohn's disease. It is mainly induced by malnutrition and the effects of the inflammatory process on the growth hormone/insulin-like growth factor-1 axis or on the growth plate. Therefore, control of disease activity and mucosal healing are paramount to promote growth and adequate pubertal onset. Current therapeutic strategies for maintenance in IBD include anti-inflammatory drugs, immunosuppressives, and, more recently, biologic agents. Although these treatments are efficient in minimizing inflammation and inducing prolonged remission, their long-term effects on growth and final height remain controversial. Furthermore, glucocorticoid therapy, even though very efficient in inducing remission, clearly shows deleterious effects on growth, which is not the case for exclusive enteral nutrition showing comparable results regarding induction of remission. Thus regular assessment of weight, height and pubertal stage is essential in children and adolescents with chronic disease, namely IBD.
Pubmed
Web of science
Création de la notice
23/07/2012 10:52
Dernière modification de la notice
03/03/2018 13:38
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