Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor.

Détails

ID Serval
serval:BIB_0C47AC69F0B5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor.
Périodique
Journal of neurosurgery
Auteur(s)
Tuleasca C., Régis J., Najdenovska E., Witjas T., Girard N., Bolton T., Delaire F., Vincent M., Faouzi M., Thiran J.P., Bach Cuadra M., Levivier M., Van de Ville D.
ISSN
1933-0693 (Electronic)
ISSN-L
0022-3085
Statut éditorial
Publié
Date de publication
01/12/2018
Peer-reviewed
Oui
Volume
129
Numéro
Suppl1
Pages
63-71
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
OBJECTIVEEssential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic deep brain stimulation or radiofrequency thalamotomy or, alternatively, minimally invasive techniques, including stereotactic radiosurgery (SRS) and high-intensity focused ultrasound, at the level of the ventral intermediate nucleus (Vim). The aim of the present study was to evaluate potential correlations between pretherapeutic interconnectivity (IC), as depicted on resting-state functional MRI (rs-fMRI), and MR signature volume at 1 year after Vim SRS for tremor, to be able to potentially identify hypo- and hyperresponders based only on pretherapeutic neuroimaging data.METHODSSeventeen consecutive patients with ET were included, who benefitted from left unilateral SRS thalamotomy (SRS-T) between September 2014 and August 2015. Standard tremor assessment and rs-fMRI were acquired pretherapeutically and 1 year after SRS-T. A healthy control group was also included (n = 12). Group-level independent component analysis (ICA; only n = 17 for pretherapeutic rs-fMRI) was applied. The mean MR signature volume was 0.125 ml (median 0.063 ml, range 0.002-0.600 ml). The authors correlated baseline IC with 1-year MR signatures within all networks. A 2-sample t-test at the level of each component was first performed in two groups: group 1 (n = 8, volume < 0.063 ml) and group 2 (n = 9, volume ≥ 0.063 ml). These groups did not statistically differ by age, duration of symptoms, baseline ADL score, ADL point decrease at 1 year, time to tremor arrest, or baseline tremor score on the treated hand (TSTH; p > 0.05). An ANOVA was then performed on each component, using individual subject-level maps and continuous values of 1-year MR signatures, correlated with pretherapeutic IC.RESULTSUsing 2-sample t-tests, two networks were found to be statistically significant: network 3, including the brainstem, motor cerebellum, bilateral thalamus, and left supplementary motor area (SMA) (pFWE = 0.004, cluster size = 94), interconnected with the red nucleus (MNI -2, -22, -32); and network 9, including the brainstem, posterior insula, bilateral thalamus, and left SMA (pFWE = 0.002, cluster size = 106), interconnected with the left SMA (MNI 24, -28, 44). Higher pretherapeutic IC was associated with higher MR volumes, in a network including the anterior default-mode network and bilateral thalamus (ANOVA, pFWE = 0.004, cluster size = 73), interconnected with cerebellar lobule V (MNI -12, -70, -22). Moreover, in the same network, radiological hyporesponders presented with negative IC values.CONCLUSIONSThese findings have clinical implications for predicting MR signature volumes after SRS-T. Here, using pretherapeutic MRI and data processing without prior hypothesis, the authors showed that pretherapeutic network interconnectivity strength predicts 1-year MR signature volumes following SRS-T.
Mots-clé
Aged, Aged, 80 and over, Brain/diagnostic imaging, Brain/physiopathology, Essential Tremor/diagnostic imaging, Essential Tremor/physiopathology, Essential Tremor/radiotherapy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways/diagnostic imaging, Neural Pathways/physiopathology, Radiosurgery, Rest, Treatment Outcome, AC = anterior commissure, ADL = activities of daily living, BOLD = blood oxygenation level–dependent, DBS = deep brain stimulation, DMN = default-mode network, DTI = diffusion tensor imaging, ET = essential tremor, FEW = family-wise error, Gamma Knife, IC = interconnectivity, ICA = independent component analysis, MNI = Montreal Neurological Institute, PC = posterior commissure, SMA = supplementary motor area, SRS = stereotactic radiosurgery, SRS-T = SRS thalamotomy, TSTH = tremor score on the treated hand, Vim, Vim = ventral intermediate nucleus, resting-state fMRI, rs-fMRI = resting-state functional MRI, stereotactic radiosurgery, thalamotomy
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/01/2019 12:39
Dernière modification de la notice
18/09/2019 6:10
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