CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy international registry: Design and rationale of the DERIVATE study.

Détails

ID Serval
serval:BIB_0C15BB848D9D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DebrillAtor ThErapy international registry: Design and rationale of the DERIVATE study.
Périodique
International journal of cardiology
Auteur(s)
Guaricci A.I., Masci P.G., Lorenzoni V., Schwitter J., Pontone G.
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Statut éditorial
Publié
Date de publication
15/06/2018
Peer-reviewed
Oui
Volume
261
Pages
223-227
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
Implantable cardioverter defibrillator (ICD) represents the most valuable sudden cardiac death (SCD) prophylactic strategy in patients with heart failure and severely reduced left ventricular ejection fraction (LVEF). To date, it is still unknown how to integrate the information given by cardiac magnetic resonance (CMR) into clinical and transthoracic echocardiography (TTE) work-up of non-ischemic cardiomyopathy (NICM) and ischemic cardiomyopathy (ICM) patients for accurate risk stratification.
DERIVATE is a prospective, international, multicenter, observational registry of NICM and ICM patients with chronic heart failure and reduced LVEF who will undergo clinical evaluation, TTE and CMR. The registry will enrol cohorts from 34 sites. Complete risk factor, clinical presentation, TTE and CMR data will be collected and each patient will be followed-up for outcomes. Primary end point of the study is all-cause mortality. Secondary end points are: cardiovascular death, SCD, aborted SCD, sustained ventricular tachycardia (VT), and major adverse cardiac events (MACE) defined as a composite endpoint of SCD, aborted SCD, and sustained VT. Specifically, we will determine CMR findings that predict outcomes, with incremental value over LVEF and NYHA classification. Secondary aims consist in providing a comprehensive clinical and imaging score and testing the contribution of machine learning to determine prognostic CMR parameters.
The final objective of the study consists in the identification of prognostic CMR parameters in a large prospective cohort for a better selection of patients with heart failure being worthy of primary prevention ICD therapy. (clinicaltrials.gov registration: RTT# NCT03352648).
Mots-clé
Defibrillators, Implantable/trends, Female, Heart Failure/diagnostic imaging, Heart Failure/epidemiology, Heart Failure/therapy, Humans, Internationality, Magnetic Resonance Imaging, Cine/methods, Magnetic Resonance Imaging, Cine/trends, Male, Primary Prevention/methods, Primary Prevention/trends, Prospective Studies, Registries, Dilated cardiomyopathy, Echocardiography, Magnetic resonance, Primary prevention, Prognosis
Pubmed
Web of science
Création de la notice
22/03/2018 20:02
Dernière modification de la notice
20/08/2019 13:33
Données d'usage