Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_0C060FA85234
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Etiology, Pathogenesis, Diagnosis, and Practical Implications of Hepatocellular Neoplasms.
Journal
Cancers
Author(s)
Hytiroglou P., Bioulac-Sage P., Theise N.D., Sempoux C.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
28/07/2022
Peer-reviewed
Oui
Volume
14
Number
15
Pages
3670
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Hepatocellular carcinoma (HCC), a major global contributor of cancer death, usually arises in a background of chronic liver disease, as a result of molecular changes that deregulate important signal transduction pathways. Recent studies have shown that certain molecular changes of hepatocarcinogenesis are associated with clinicopathologic features and prognosis, suggesting that subclassification of HCC is practically useful. On the other hand, subclassification of hepatocellular adenomas (HCAs), a heterogenous group of neoplasms, has been well established on the basis of genotype-phenotype correlations. Histologic examination, aided by immunohistochemistry, is the gold standard for the diagnosis and subclassification of HCA and HCC, while clinicopathologic correlation is essential for best patient management. Advances in clinico-radio-pathologic correlation have introduced a new approach for the diagnostic assessment of lesions arising in advanced chronic liver disease by imaging (LI-RADS). The rapid expansion of knowledge concerning the molecular pathogenesis of HCC is now starting to produce new therapeutic approaches through precision oncology. This review summarizes the etiology and pathogenesis of HCA and HCC, provides practical information for their histologic diagnosis (including an algorithmic approach), and addresses a variety of frequently asked questions regarding the diagnosis and practical implications of these neoplasms.
Keywords
LI-RADS, diagnostic algorithm, frequently asked questions, hepatocellular adenoma, hepatocellular carcinoma, histologic diagnosis, molecular pathology
Pubmed
Web of science
Open Access
Yes
Create date
15/08/2022 8:25
Last modification date
23/08/2022 6:08
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