Consensus statement on safety measures for pressurized intraperitoneal aerosol chemotherapy.

Details

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_0BFCEFE1FE4D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Consensus statement on safety measures for pressurized intraperitoneal aerosol chemotherapy.
Journal
Pleura and peritoneum
Author(s)
Girardot-Miglierina A., Clerc D., Alyami M., Villeneuve L., Sgarbura O., Reymond M.A., Hübner M.
Working group(s)
ISSPP PIPAC study group
ISSN
2364-768X (Electronic)
ISSN-L
2364-768X
Publication state
Published
Issued date
12/2021
Peer-reviewed
Oui
Volume
6
Number
4
Pages
139-149
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising treatment for peritoneal cancer that entails, however, potential risks for the caregivers in the operating room (OR). This study aimed to reach a consensus within the PIPAC community on a comprehensive safety protocol.
Active PIPAC centers were invited to participate in a two-round Delphi process on 43 predefined items: concise summaries of the existing evidence were presented together with questions formulated using the population, intervention, comparator, and outcome framework. According to the Grading of Recommendations Assessment, Development, and Evaluation, the strength of recommendation was voted by panelists, accepting a consensus threshold of ≥50% of the agreement for any of the four grading options, or ≥70% in either direction.
Forty-seven out of 66 invited panelists answered both rounds (response rate 76%). The consensus was reached for 41 out of 43 items (95.3%). Strong and weak recommendations were issued for 30 and 10 items, respectively. A positive consensual recommendation was issued to activate laminar airflow without specific strength, neither strong nor weak. No consensus was reached for systematic glove change for caregivers with a high risk of exposure and filtering facepiece mask class 3 for caregivers with low risk of exposure.
A high degree of consensus was reached for a comprehensive safety protocol for PIPAC, adapted to the risk of exposure for the different caregivers in the OR. This consensus can serve as a basis for education and help reach a high degree of adherence in daily practice.
Keywords
Internal Medicine, PIPAC, education and training, expert consensus, personal protective equipment, safety
Pubmed
Web of science
Open Access
Yes
Create date
14/01/2022 17:53
Last modification date
05/04/2023 5:55
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