Drosophila melanogaster dHCF Interacts with both PcG and TrxG Epigenetic Regulators.

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_0B43BEBE64F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Drosophila melanogaster dHCF Interacts with both PcG and TrxG Epigenetic Regulators.
Périodique
PLoS One
Auteur(s)
Rodriguez-Jato S., Busturia A., Herr W.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2011
Volume
6
Numéro
12
Pages
e27479
Langue
anglais
Résumé
Repression and activation of gene transcription involves multiprotein complexes that modify chromatin structure. The integration of these complexes at regulatory sites can be assisted by co-factors that link them to DNA-bound transcriptional regulators. In humans, one such co-factor is the herpes simplex virus host-cell factor 1 (HCF-1), which is implicated in both activation and repression of transcription. We show here that disruption of the gene encoding the Drosophila melanogaster homolog of HCF-1, dHCF, leads to a pleiotropic phenotype involving lethality, sterility, small size, apoptosis, and morphological defects. In Drosophila, repressed and activated transcriptional states of cell fate-determining genes are maintained throughout development by Polycomb Group (PcG) and Trithorax Group (TrxG) genes, respectively. dHCF mutant flies display morphological phenotypes typical of TrxG mutants and dHCF interacts genetically with both PcG and TrxG genes. Thus, dHCF inactivation enhances the mutant phenotypes of the Pc PcG as well as brm and mor TrxG genes, suggesting that dHCF possesses Enhancer of TrxG and PcG (ETP) properties. Additionally, dHCF interacts with the previously established ETP gene skd. These pleiotropic phenotypes are consistent with broad roles for dHCF in both activation and repression of transcription during fly development.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/01/2012 16:42
Dernière modification de la notice
08/05/2019 14:15
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