Neuroendocrine breast cancer: retrospective analysis of 96 patients and review of literature.

Détails

ID Serval
serval:BIB_0B2F7B221A27
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neuroendocrine breast cancer: retrospective analysis of 96 patients and review of literature.
Périodique
International Journal of Surgery (london, England)
Auteur(s)
Rovera F., Lavazza M., La Rosa S., Fachinetti A., Chiappa C., Marelli M., Sessa F., Giardina G., Gueli R., Dionigi G., Rausei S., Boni L., Dionigi R.
ISSN
1743-9159 (Electronic)
ISSN-L
1743-9159
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
11
Numéro
Suppl 1
Pages
S79-S83
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: Primary neuroendocrine breast carcinomas (NEBC) are uncommon lesions; they constitute approximately 1% of all breast cancers and mostly affect elderly patients. According to the most recent World Health Organization classification, it concerns almost exclusively the female population between the sixth and seventh decades. The aim of this retrospective study is to analyze the clinicopathological aspects of 96 NEBC patients who had undergone surgical resection at a single institute.
METHODS: We retrospectively analyzed a series of 96 patients who underwent surgical resection for NEBC between January 1992 and August 2013.
RESULTS: The 96 patients with NEBC were divided into two categories: 61 (63.5%) in whom the expression of a neuroendocrine marker was present in more than 50% of neoplastic cells and 35 (36.5%) with a minor neuroendocrine component. Our data show a mean age of the patients at diagnosis of 70 years (range 42-87 years); the 10-year survival of the 96 patients was 87%, moreover we report tumor location, type of surgical operation, tumor size (average 2.1 cm), hormone therapy, chemotherapy and radiotherapy if used, recurrence sites, overall and disease free survival times.
CONCLUSIONS: This study showed a better prognosis in patients with NEBC compared with breast carcinomas with a minor neuroendocrine component and with conventional invasive ductal or lobular cancers.
Mots-clé
Adult, Aged, Breast Neoplasms/pathology, Breast Neoplasms/surgery, Carcinoma, Neuroendocrine/pathology, Carcinoma, Neuroendocrine/surgery, Female, Humans, Middle Aged, Retrospective Studies, Survival Analysis
Pubmed
Open Access
Oui
Création de la notice
07/09/2016 10:24
Dernière modification de la notice
20/08/2019 12:32
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