Effect of metoclopramide on angiotensins, aldosterone, and atrial peptide during hypoxia.

Details

Serval ID
serval:BIB_0B11214B2ADE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of metoclopramide on angiotensins, aldosterone, and atrial peptide during hypoxia.
Journal
Journal of Applied Physiology
Author(s)
Vonmoos S., Nussberger J., Waeber B., Biollaz J., Brunner H.R., Leuenberger P.
ISSN
8750-7587 (Print)
ISSN-L
0161-7567
Publication state
Published
Issued date
1990
Peer-reviewed
Oui
Volume
69
Number
6
Pages
2072-2077
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The coupling of aldosterone with renin is altered during acute hypoxemia. We measured the various components of the renin-angiotensin system and the plasma levels of immunoreactive atrial natriuretic factor (iANF) during room air and hypoxic gas-mixture breathing before and after administration of metoclopramide, a competitive antagonist of dopamine. Seven resting volunteers were studied 1 wk apart under room air and hypoxic conditions (inspired O2 fraction 0.12). During hypoxemia, the release of aldosterone induced by metoclopramide was significantly smaller. This change was associated with a slight increase in iANF and with a decrease in plasma angiotensin II levels, without any change in immunoreactive blood angiotensin I concentrations. Plasma electrolytes and blood acid-base status did not show relevant changes, nor did blood pressure and heart rate. We conclude that the decreased aldosterone concentrations seen under hypoxemia are related to decreased angiotensin II levels. Other influences, such as elevated ANF, may also mediate this effect.
Keywords
Adult, Aldosterone/blood, Angiotensin I/blood, Angiotensin II/blood, Anoxia/physiopathology, Atrial Natriuretic Factor/blood, Blood Pressure/drug effects, Heart Rate/drug effects, Humans, Metoclopramide/pharmacology, Oxygen/blood, Potassium/blood, Reference Values, Renin-Angiotensin System/drug effects, Sodium/blood
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 12:32
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